How Does the Eukaryotic Initiation Complex Locate the Correct Start

Question

How does the eukaryotic initiation complex locate the correct start codon?
A) The initiation complex moves the small ribosomal subunit through the 5' UTR, scanning for the start AUG.
B) The correct start codon is the first ATG encountered downstream of the Kozak sequence.
C) The pre- initiation complex moves the ribosome through the 3' UTR, scanning for the Kozak sequence.
D) The correct start codon is the formyl- ATG, which will encode for fMet in the protein.
E) The true start codon is the first ATG encountered downstream of the Shine- Dalgarno sequence.

Accepted Answer

The eukaryotic initiation complex scans the mRNA from the 5' end, moving the small ribosomal subunit along the 5' UTR to locate the start codon, typically AUG, within the context of a Kozak sequence.