Which of the Following Events is Known to Make DNA

Question

Which of the following events is known to make DNA more sensitive to digestion by DNase I?
A) DNA methylation
B) deacetylation of histone
C) acetylation of histone
D) formation of heterochromatin

Accepted Answer

Acetylation of histones reduces the positive charge on histones, decreasing their interaction with negatively charged DNA. This results in a more open chromatin structure, making DNA more accessible and sensitive to DNase I digestion.