Substrate Activation May Involve

Question

Substrate activation may involve
A)a change in enzyme conformation induced by substrate binding.
B)accepting protons from the enzyme.
C)formation of temporary covalent bonds.
D)donation of protons to the enzyme.
E)All of these are correct.

Accepted Answer

Substrate activation can involve a variety of mechanisms including a change in enzyme conformation upon substrate binding, the transfer of protons to or from the enzyme, and the formation of temporary covalent bonds between the enzyme and substrate. These processes help in lowering the activation energy for the reaction, thereby increasing the rate of the reaction.