Which of the Following May Result in Point Mutations That

Question

Which of the following may result in point mutations that can contribute to cancer?
A)Deamination of 5-methylcytosine
B)Unrepaired single-strand breaks during DNA synthesis
C)Microsatellite instability
D)Exposure to UV radiation
E)All of the above

Accepted Answer

All of the above options may result in point mutations that can contribute to cancer. 
- Deamination of 5-methylcytosine can result in a C to T transition mutation, which may lead to changes in the protein-coding sequence and contribute to cancer development.
- Unrepaired single-strand breaks during DNA synthesis can lead to errors in replication and mutations, which may contribute to cancer when the mutations affect genes involved in cell cycle regulation or DNA repair.
- Microsatellite instability is a type of DNA replication error that can result in changes in the number of repeats of short DNA sequences, which can affect gene expression and contribute to cancer development.
- Exposure to UV radiation can cause DNA damage, including the formation of pyrimidine dimers, which may result in mutations that contribute to skin cancer development.