Mice in Which the TGF-β Type II Receptor was Inactivated

Question

Mice in which the TGF-β type II receptor was inactivated in stromal fibroblasts exhibited
A)Increased incidence of carcinomas.
B)Reduced incidence of carcinomas.
C)Stromal hyperplasia.
D)A and C.
E)All of the above.

Accepted Answer

Mice with the TGF-β type II receptor inactivated in stromal fibroblasts showed an increased incidence of carcinomas and stromal hyperplasia, indicating the critical role of TGF-β signaling in stromal fibroblasts in suppressing tumor formation and maintaining stromal integrity.