Gleevec Has Been Used to Successfully Treat Patients with CML

Question

Gleevec has been used to successfully treat patients with CML by targeting
A)Anti-apoptotic proteins.
B)The kinase activity of the Bcr-Abl fusion protein.
C)Oncogenic H-Ras signaling.
D)The antigenic proteins on the surface of leukemia cells.
E)None of the above.

Accepted Answer

Gleevec targets the kinase activity of the Bcr-Abl fusion protein, which is typically overexpressed in patients with CML. This inhibits the proliferation of leukemia cells and induces their apoptosis, leading to successful treatment outcomes in many patients.