Acute Promyelocytic Anemia APL)has Been Treated with All-Trans-Retinoic Acid ATRA),which

Question

Acute promyelocytic anemia APL)has been treated with all-trans-retinoic acid ATRA),which results in
A)Killing of malignant cells by NK cells.
B)Initiation of the humoral immune response.
C)Attraction of cytokines to the tumor site.
D)The differentiation of leukemic cells into neutrophils.
E)None of the above.

Accepted Answer

ATRA is a treatment for APL because it induces terminal differentiation of promyelocytes into mature neutrophils. This leads to the restoration of normal hematopoiesis and the reduction of the leukemia burden. Options A, B, and C are not correct because they are not directly related to ATRA treatment for APL.