The mechanisms underlying the development of cardiac hypertrophy are complex,although relaxation abnormalities that result in chronic elevation of cytosolic Ca++ level appear to promote the development of hypertrophy through:
A)Stimulation of the sarcolemmal Ca++ pump.
B)Ca++ binding to troponin I.
C)Activation of calcineurin.
D)Inhibition of Ca++/calmodulin-dependent protein kinase.
E)Opening of Ca++-activated K+ channels.