Question 7

(Multiple Choice)

Mutations in the cardiac ryanodine receptor have been associated with cardiac arrhythmias.Specifically,a mutation in the cardiac ryanodine receptor that increases Ca++ efflux from the SR promotes the development of delayed afterdepolarizations by:


A)Decreasing the activity of calcineurin.
B)Increasing Ca++ efflux through the Na+-Ca++ antiporter.
C)Increasing mitochondrial Ca++ uptake.
D)Decreasing actin-myosin interactions.
E)Increasing the activity of K+ channels.

Answer