Cushing's Disease is Caused by an ACTH-Oversecreting Pituitary Tumor

Question

Cushing's disease is caused by an ACTH-oversecreting pituitary tumor.One of the effects of this is:
A)Increased skeletal muscle mass.
B)Decreased catecholamine responsiveness in the heart.
C)Anorexia.
D)Insulin resistance.
E)Decreased glucagon responsiveness in adipose tissue.

Accepted Answer

Cushing's disease leads to excess cortisol secretion which can cause insulin resistance. This is because cortisol opposes the action of insulin and can lead to impaired glucose uptake and utilization by cells.