Why do you think there are so many types of presynaptic proteins involved in neurotransmitter release?

This is a thought question with many possible answers. Reasons could include regulation of neurotransmitter release. Neurotransmission should occur when it is needed. If it occurs at other times this can lead to incorrect information transfer. Neurotransmission must be tightly regulated, but also be able to be modified as the activity of the neuron must change frequently and rapidly depending on the current state of the neuron. Many of the proteins are there to make sure everything is in the right place. For example, some proteins make sure vesicles are located next to Ca²⁺ channels to make sure synaptic transmission is efficient.