What is the Current Known Role of Complexin in Synaptic

Question

What is the current known role of complexin in synaptic transmission? A) Complexin makes sure vesicles are near Ca²⁺ channels. B) Complexin binds vesicles to scaffolding proteins in the presynaptic membrane. C) Complexin clamps the SNARE complex in an intermediate step prior to vesicle fusion. D) Complexin is required for presynaptic Ca²⁺ channels to open.

Accepted Answer

The RIMs help place Ca²⁺ channels near vesicles. For (b), complexin binds the SNARE complex, not scaffolding proteins. A depolarization is required for most presynaptic calcium channels to open.