Question 1

(Essay)

What effects would you expect to see on the sizes of various areas of the telencephalon-primary visual cortex, primary somatosensory cortex, and frontal/motor cortex-if Wnt signaling were inhibited during anteroposterior patterning of the neural tube?

Answer

BMPs/Wnt signaling promotes expression of Emx2, which in turn leads to differentiation of posterior structures such as primary visual cortex (V1). Reducing BMP/Wnt signaling should lead to an expansion of anterior structures such as primary somatosensory cortex (S1) and frontal/motor cortex (F/M) at the expense of primary visual cortex, similar to an Emx2 knockout.