Which of the Following Statements Applies to Frameshift Mutations

Question

Which of the following statements applies to frameshift mutations?
A)They cause the insertion or deletion of a single amino acid from the polypeptide chain.
B)They create a premature stop codon at the site of mutation.
C)They change the amino acid sequence downstream from the mutant site.
D)They are known risk factors in most forms of cancer, including breast and colon cancer.
E)They are known risk factors in breast cancer, but not colon cancer.

Accepted Answer

Frameshift mutations result from insertions or deletions of a number of nucleotides that are not divisible by three, leading to a shift in the reading frame of the genetic code. This shift changes the amino acid sequence downstream from the mutation site.