Which of the following statements is not true regarding the region of primary ossification of a bone?

A) Osteoblasts are derived from the newly formed periosteum.
B) Bone formation spreads from the center to the ends of the bone.
C) As the cartilage models calcify, the chondrocytes die off.
D) The region of primary ossification is where osteoclasts are laid down on the outside of the bone.
E) A band of cartilage remains between the primary ossification center and each secondary center.