Which of the Following Disorders is a Trinucleotide Repeat Disorder

Question

Which of the following disorders is a trinucleotide repeat disorder?
A) Marfan syndrome
B) sickle-cell disease
C) cystic fibrosis
D) Tay-Sachs disease
E) Huntington disease

Accepted Answer

Huntington disease is a trinucleotide repeat disorder. It is caused by the expansion of CAG repeats in the HTT gene, leading to the production of a toxic protein that causes neurodegeneration. Marfan syndrome is caused by mutations in the FBN1 gene, sickle-cell disease is caused by a point mutation in the beta-globin gene, cystic fibrosis is caused by mutations in the CFTR gene, and Tay-Sachs disease is caused by mutations in the HEXA gene. None of these disorders are trinucleotide repeat disorders.