Which Diseases are Associated with Imprinting

Question

Which diseases are associated with imprinting?
A) Angelman Syndrome
B) LHON
C) Alzheimer's Disease
D) All of the answers are correct

Accepted Answer

Angelman Syndrome is a rare neuro-genetic disorder caused by a lack of function of the UBE3A gene, which is a result of either a deletion in chromosome 15 or a mutation of the UBE3A gene. This gene is expressed primarily from the maternal chromosome, and the loss of its expression in the brain during development leads to Angelman Syndrome. This disease is an example of imprinting. LHON and Alzheimer's Disease are not associated with imprinting.