A Mutation in TFIIIE Could Result In

Question

A mutation in TFIIIE could result in
A) a failure of the RNA polymerase to bind to TFIIB
B) a failure of the RNA polymerase to maintain an closed complex
C) a failure of the RNA polymerase to maintain an open complex
D) no effect on transcription

Accepted Answer

TFIIIE is responsible for maintaining an open complex during transcription, which is essential for RNA polymerase to initiate elongation. Therefore, a mutation in TFIIIE could result in a failure of the RNA polymerase to maintain an open complex, leading to transcriptional failure.