Which One of the Following Directly Interacts with the DNA

Question

Which one of the following directly interacts with the DNA as a transcriptional regulator?
A) cAMP
B) G protein
C) Protein kinase A
D) CREB protein dimer
E) Glucocorticoid response element

Accepted Answer

The CREB (cAMP response element-binding) protein dimer directly interacts with DNA as a transcriptional regulator. It binds to specific DNA sequences called cAMP response elements (CREs) and regulates gene expression. Option A (cAMP) is a signaling molecule that can activate Protein kinase A (option C) but does not directly interact with DNA. Option B (G protein) is a signaling molecule that regulates downstream effectors but does not directly interact with DNA. Option E (Glucocorticoid response element) is a specific DNA sequence that binds to glucocorticoid receptors but is not a transcriptional regulator in itself.