What Activates CREB

Question

What activates CREB?
A) Binding of cAMP
B) Phosphorylation
C) Dimerization
D) Lowering of cAMP concentration
E) Binding to GRE

Accepted Answer

CREB (cAMP response element-binding protein) is activated by phosphorylation, which is typically mediated by protein kinase A (PKA) in response to increased levels of cAMP.