Which of the Following is Part of the Mechanism for Epigenetic

Question

Which of the following is part of the mechanism for epigenetic regulation of the Igf-2 gene
A) Methylation of the H19 locus
B) Methylation of the ICR and DMR domains
C) Binding of CTC factors to methylated sequences
D) Answers B and C are correct
E) Answers A and C are correct

Accepted Answer

Epigenetic regulation of the Igf-2 gene involves methylation of the ICR (imprinting control region) and DMR (differentially methylated region) domains, which affects the binding of transcription factors. Additionally, CTCF (CCCTC-binding factor) proteins bind to the methylated sequences and further regulate the gene expression. Methylation of the H19 locus is also involved in the regulation of the Igf-2 gene, but this is not the mechanism for epigenetic regulation. Therefore, answer option D, which includes both correct statements, is the best choice.