Chronic Myelogenous Leukemia is an Example of a Proto-Oncogene Activation

Question

Chronic myelogenous leukemia is an example of a proto-oncogene activation by ________.
A) Action of a virus
B) Missense mutation
C) A translocation
D) Gene amplification
E) None of the answers are correct

Accepted Answer

Chronic myelogenous leukemia is caused by the Philadelphia chromosome, which is a translocation between chromosomes 9 and 22. This results in the activation of the BCR-ABL fusion gene, which acts as a constitutively active tyrosine kinase and drives the uncontrolled proliferation of white blood cells.