An Oncogene Form of Ras Would Have ________

Question

An oncogene form of Ras would have ________.
A) decreased GTPase activity
B) an inability to bind GTP
C) increased susceptibility to growth factors
D) inability to bind Raf-1

Accepted Answer

Oncogenic forms of Ras have decreased GTPase activity, which means they are less able to hydrolyze GTP to GDP. This results in the Ras protein being "stuck" in its active GTP-bound state, continuously signaling for cell growth and division, which can lead to cancer.