During Endochondral Ossification, Deposition of Calcium Salts Leads to the Death

Question

During endochondral ossification, deposition of calcium salts leads to the death of
A)osteoclasts.
B)chondrocytes.
C)osteoblasts.
D)osteocytes

Accepted Answer

Endochondral ossification is the process of bone formation that occurs by the replacement of hyaline cartilage with bone tissue. The calcification of the cartilage matrix ultimately leads to the death of chondrocytes, which then stimulates the invasion of blood vessels and the differentiation of osteoblasts from mesenchymal stem cells. Osteoblasts then deposit bone tissue on the surface of the remaining calcified cartilage, leading to the formation of mature bone. Osteoclasts play a role in bone remodeling, but they are not directly involved in endochondral ossification. Osteocytes are mature bone cells that maintain bone tissue but do not play a significant role in the formation of new bone.