Liver Pyruvate Kinase is Activated by Dephosphorylation in Response to Glucagon

Question

Liver pyruvate kinase is activated by dephosphorylation in response to glucagon.

Accepted Answer

Liver pyruvate kinase is actually inhibited by phosphorylation in response to glucagon, not activated. This is because glucagon signals a need for glucose production by the liver, and inhibiting pyruvate kinase helps divert glucose precursors towards gluconeogenesis instead of glycolysis.