Glycolysis is Regulated Primarily By

Question

Glycolysis is regulated primarily by:
A) the availability of glucose-6-phosphate.
B) three strongly endergonic, nonequilibrium reactions.
C) three strongly exergonic, nonequilibrium reactions.
D) allosteric effectors of pyruvate kinase.
E) phosphorylation of phosphofructokinase.

Accepted Answer

Glycolysis is primarily regulated by three strongly exergonic, nonequilibrium reactions. These reactions include hexokinase, phosphofructokinase, and pyruvate kinase.

Answer: D 
 Pyruvate kinase is regulated by allosteric effectors such as ATP, which inhibits the enzyme, and fructose-1,6-bisphosphate, which activates it. However, this is not the primary regulation point for glycolysis.