The PKa of Each Amino Acid Residue in a Protein

Question

The pKa of each amino acid residue in a protein will not be influenced by the adjacent residue.

Accepted Answer

The pKa of an amino acid residue in a protein can be influenced by the nearby charged or polar residues. This is known as electrostatic interaction. The neighboring residues can affect the polarity of the amino acid residue side chain and thus, affect its pKa value.