At PH=0, the Net Charge on a Polypeptide Will Be

Question

At pH=0, the net charge on a polypeptide will be negative.

Accepted Answer

At pH=0, the environment is highly acidic, leading to the protonation of acidic and basic groups on the polypeptide. This generally results in a net positive charge, as the amino groups are protonated and the carboxyl groups are less likely to lose a proton in such an acidic environment.