Which of the following is true regarding the Briggs and Haldane steady state assumption?

A) It is defined by the equation

B) It states the rate of enzyme-substrate complex formation differs from the rate of enzyme-substrate disappearance.
C) The concentration of the enzyme-substrate complex reaches a constant value even in a dynamic system.
D) The enzyme-substrate complex will always dissociate to form E + P.
E) The total amount of enzyme is variable, depending on the amount of substrate available.