For Phosphofructokinase-1

Question

For phosphofructokinase-1:
A) Low ATP stimulates the enzyme, but fructose-2,6-bisphosphate inhibits
B) High ATP stimulates the enzyme, and fructose-2,6-bisphosphate activates
C) High ATP stimulates the enzyme, but fructose-2,6-bisphosphate inhibits
D) Low ATP stimulates the enzyme, and fructose-2,6-bisphosphate activates
E) ATP and fructose-2,6-bisphosphate both inhibit the enzyme

Accepted Answer

Low ATP levels indicate a need for energy, stimulating phosphofructokinase-1 to increase glycolysis. Fructose-2,6-bisphosphate is a potent activator of the enzyme, promoting glycolysis even further.