The Committed Step in Fatty Acid Biosynthesis, Formation of Malonyl-CoA

Question

The committed step in fatty acid biosynthesis, formation of malonyl-CoA, is catalyzed by:
A) fatty acid synthase.
B) pyruvate carboxylase.
C) propionate carboxylase.
D) acetyl-CoA carboxylase.
E) ATP-citrate lyase.

Accepted Answer

The committed step in fatty acid biosynthesis is the formation of malonyl-CoA from acetyl-CoA. This reaction is catalyzed by the enzyme acetyl-CoA carboxylase. The other options listed here are not involved in this specific pathway.