The Main Source(s) of NADPH for Fatty Acid Biosynthesis Is

Question

The main source(s) of NADPH for fatty acid biosynthesis is (are):
A) TCA cycle.
B) oxidative phosphorylation.
C) malic enzyme and the pentose phosphate pathway.
D) the conversion of OAA to malate by malate dehydrogenase.
E) glycolysis.

Accepted Answer

NADPH is required for the reduction of fatty acids, and its main source for fatty acid biosynthesis is the oxidative pentose phosphate pathway and malic enzyme. The TCA cycle and oxidative phosphorylation primarily produce NADH, while the conversion of OAA to malate by malate dehydrogenase generates NADH, but not NADPH. Glycolysis produces a small amount of NADPH, but it is not a significant source for fatty acid biosynthesis.