N-Acetylglutamate Functions in Ammonium Incorporation into Metabolic Intermediates As

Question

N-acetylglutamate functions in ammonium incorporation into metabolic intermediates as:
A) a coenzyme for glutamine synthetase (GS).
B) a competitive inhibitor for glutamine synthetase (GS).
C) an allosteric activator for carbamoyl-phosphate synthetase I (CPS-I).
D) the energy source needed for the reductive amination of α-ketoglutarate (α-KG) to yield glutamate.
E) the substrate for the amination of the γ-glutamylphosphate.

Accepted Answer

N-acetylglutamate acts as an allosteric activator for carbamoyl-phosphate synthetase I (CPS-I), which is involved in ammonium incorporation into metabolic intermediates such as the urea cycle. N-acetylglutamate does not function as a coenzyme for glutamine synthetase (GS) or the energy source needed for the reductive amination of α-ketoglutarate (α-KG) to yield glutamate, nor is it a substrate for the amination of the γ-glutamylphosphate. N-acetylglutamate also does not function as a competitive inhibitor for GS.