The Primary Driving Force for Folding Is/are ____ and If

Question

The primary driving force for folding is/are ____ and if crowding occurs then ____ is likely.
A) hydrogen bonding; dehydration
B) hydrogen bonding; non-specific bonding
C) hydrophobic interactions; aggregation
D) hydrophilic interactions; non-specific binding
E) none are true

Accepted Answer

The primary driving force for folding is hydrophobic interactions between nonpolar amino acids. If crowding occurs, then aggregation of the protein is likely to occur.