Acetylated Histonesــــــــــــــــــــــــ

Question

Acetylated histonesــــــــــــــــــــــــ .
A)form highly condensed heterochromatin
B)are a target of proteases
C)never occurs
D)allow nucleosomes to be less aggregated

Accepted Answer

Acetylated histones allow for nucleosomes to be less aggregated, which in turn allows for greater accessibility of DNA to transcription factors and enzymes. This leads to more active transcription of genes. Acetylation of histones occurs through the transfer of an acetyl group from acetyl-CoA to the lysine residue on the histone protein, and it is critical for regulating transcriptional activity. Acetylation of histones does not lead to the formation of highly condensed heterochromatin, nor is it a target of proteases.