Which of the Following Types of DNA Repair is Often

Question

Which of the following types of DNA repair is often coupled with transcription?
A)photoreactivation
B)base excision repair
C)replication
D)nucleotide excision repair
E)all of the above

Accepted Answer

Nucleotide excision repair is often coupled with transcription because it can repair bulky lesions such as pyrimidine dimers that can obstruct RNA polymerase during transcription. This repair mechanism removes a patch of 24-32 nucleotides containing the damage, which can then be filled in by DNA polymerase and ligase. The other types of DNA repair listed do not have a direct relationship with transcription.