Which of the Following Describes the Coenzyme Involved with Thymidylate

Question

Which of the following describes the coenzyme involved with thymidylate synthase?
A)5-methyl-THF serves as the methyl donor
B)10-methyl-THF serves as the methyl donor
C)5,10-methylene-THF serves as both methylene donor and reducing agent
D)5,10-methenyl-THF serves as both methylene donor and reducing agent
E)S-adenosylmethionine serves as the methyl donor

Accepted Answer

5,10-methylene-THF serves as both the methylene donor and reducing agent in the reaction catalyzed by thymidylate synthase, which is crucial for the synthesis of thymidine monophosphate (TMP), a nucleotide required for DNA synthesis and repair.