Which of the Following is the Most Important Regulatory Enzyme

Question

Which of the following is the most important regulatory enzyme in fatty acid synthesis?
A)citrate lyase
B)malic enzyme
C)acetyl-CoA carboxylase
D)acetyl-CoA-ACP transacylase
E)malonyl-CoA-ACP transacylase

Accepted Answer

Acetyl-CoA carboxylase is the most important regulatory enzyme in fatty acid synthesis because it catalyzes the conversion of acetyl-CoA to malonyl-CoA, which is the first committed step in the synthesis of fatty acids. This enzyme is regulated by hormonal and nutritional signals, including insulin, glucagon, and AMPK, and is therefore critical in maintaining lipid homeostasis in the body. The other enzymes listed are also involved in fatty acid synthesis, but they are not as crucial in regulation as acetyl-CoA carboxylase.