Which Enzyme Catalyzes the Primary Regulation Site of Glycolysis

Question

Which enzyme catalyzes the primary regulation site of glycolysis?
A)hexokinase
B)phosphofructokinase-1
C)glyceraldehyde-3-phosphate dehydrogenase
D)phosphoglycerate kinase
E)pyruvate kinase

Accepted Answer

Phosphofructokinase-1 (PFK-1) catalyzes the third step of glycolysis, which is considered the primary regulation site of the pathway. PFK-1 is sensitive to both the energy status of the cell (ATP/ADP ratio) and the availability of glucose. This allows it to regulate the flow of glucose through glycolysis and respond to changes in cellular energy needs.