The Formation of a Hemiacetal When Glucose Undergoes Cyclization Represents

Question

The formation of a hemiacetal when glucose undergoes cyclization represents what type of reaction?
A)nucleophilic substitution
B)nucleophilic addition
C)carbonyl condensation
D)elimination
E)oxidation

Accepted Answer

The formation of a hemiacetal occurs when the carbonyl group of glucose reacts with the hydroxyl group in the same molecule in the presence of an acid catalyst. This reaction is a nucleophilic addition, as the hydroxyl group acts as a nucleophile and attacks the electrophilic carbon atom in the carbonyl group.