What are the Expected Changes in Kinetics in the Presence

Question

What are the expected changes in kinetics in the presence of a competitive inhibitor?
A)Vmaxdecreases,KMappears to decrease
B)Vmaxdoes not change,KMappears to decrease
C)Vmaxdecreases,KMappears to increase
D)Vmaxdoes not change,KMappears to increase
E)Vmaxdecreases,KMdoes not change

Accepted Answer

In the presence of a competitive inhibitor, the maximum velocity (Vmax) of the enzyme-catalyzed reaction does not change because the inhibitor can be outcompeted by high substrate concentrations. However, the apparent Km (Km apparent) increases because a higher substrate concentration is required to reach half of the Vmax due to the presence of the inhibitor competing for the active site.