Based on the Following,what Can Be Said About the Synthesis

Question

Based on the following,what can be said about the synthesis of polynucleotides? 
A)polynucleotides are unstable and are rapidly degraded 
B)polynucleotide formation is made much more exergonic by the hydrolysis of pyrophosphate 
C)the hydrolysis of nucleoside triphosphates is the only driving force to make an overall irreversible reaction 
D)polynucleotides are highly resistant to hydrolysis,even in the presence of an acid catalyst 
E)none of the above

Accepted Answer

Polynucleotide synthesis involves the formation of phosphodiester bonds between nucleotides, which release pyrophosphate (PPi) as a byproduct. The hydrolysis of PPi by pyrophosphatase makes the overall reaction exergonic and drives the synthesis of polynucleotides forward. This is a key driving force for polynucleotide synthesis. The options A, C, and D are incorrect because polynucleotides are generally stable, the hydrolysis of nucleoside triphosphates is not the only driving force for polynucleotide synthesis, and polynucleotides are susceptible to hydrolysis under certain conditions.