How Does the Inactivation of Mutations in the APC Gene

Question

How does the inactivation of mutations in the APC gene initiate tumor formation?
A) By causing the development of abnormal tissues within the intestinal epithelium
B) By causing the development of abnormal tissues within the breast tissue
C) By causing the development of abnormal tissues within the connective tissue
D) By causing the development of abnormal tissues within the nervous tissue
E) By causing the development of abnormal tissues within the muscular tissue

Accepted Answer

The inactivation of mutations in the APC gene leads to the development of abnormal tissues within the intestinal epithelium, particularly in the colon. This abnormal tissue growth can progress to form polyps, which may develop into cancerous tumors over time. Breast tissue, connective tissue, nervous tissue, and muscular tissue are not typically affected by mutations in the APC gene.