Mutations in HPC1

Question

Mutations in HPC1
A) cause glioblastomas in the brain.
B) lead to prostate cancer when mutations in TP53, RB, and NF2 also occur.
C) is the gene for the inherited form of prostate cancer.
D) require mutations in several other tumor suppressor genes to cause polyposis carcinomas.
E) None of these

Accepted Answer

HPC1 is a gene that has been associated with inherited prostate cancer. Mutations in this gene are believed to increase the risk of developing prostate cancer, although other genetic and environmental factors also play a role. This gene is not associated with glioblastomas in the brain, other forms of cancer that require mutations in several other genes, or any combination of mutations with TP53, RB, and NF2.