Where are Most of the Mutations That Inactivate P53 Located

Question

Where are most of the mutations that inactivate p53 located?
A) N-terminal transcription-activation domain
B) Central DNA-binding core domain
C) C-terminal homo-oligomerization domain
D) D-terminal binding domain
E) None of these

Accepted Answer

The central DNA-binding core domain is the most important part of the p53 protein, and is responsible for binding to DNA and activating transcription of target genes. Therefore, most mutations that inactivate p53 are located in this domain. Mutations in the other domains may affect the ability of p53 to function normally, but are less common.