Tumor Suppressor Genes

Question

Tumor suppressor genes
A) were discovered by studies of rare cancers exhibiting a dominant inheritance pattern.
B) were suggested by Alfred Knudson's findings in his 1971 study of retinoblastoma.
C) function in more than one cellular process.
D) of particular classes function by binding to and inhibiting the activity of transcription factors controlling cell cycle progression.
E) All of these

Accepted Answer

A) Tumor suppressor genes were initially discovered by studying rare cancers exhibiting a dominant inheritance pattern, such as familial retinoblastoma.
B) Alfred Knudson's study of retinoblastoma suggested the two-hit hypothesis of tumor suppression, which is now widely accepted.
C) Tumor suppressor genes function in a variety of cellular processes, including DNA repair, cell cycle regulation, and apoptosis.
D) Some tumor suppressor genes inhibit the activity of transcription factors involved in cell cycle progression, such as p53. 
Therefore, all of these statements are true and the best choice is E.