Burkitts Lymphoma and Chronic Myelogenous Leukemia are Associated with Which

Question

Burkitts lymphoma and chronic myelogenous leukemia are associated with which of the following?
A) Lack of tumor suppressor genes
B) Formation of thymidine dimers due to UV light exposure
C) Mutations induced by exposure to carcinogens in cigarette smoke
D) Reciprocal translocations on chromosomes
E) None of these

Accepted Answer

Burkitt's lymphoma is associated with a reciprocal translocation between chromosomes 8 and 14, while chronic myelogenous leukemia is associated with a reciprocal translocation between chromosomes 9 and 22. These translocations lead to the activation of oncogenes or the creation of fusion proteins that drive the development of the malignancy.