Which of the Following Can Affect RNA Transcript Stability in the Cytoplasm

Question

Which of the following can affect RNA transcript stability in the cytoplasm?
A) 3' Poly A tails
B) The sequence of the 3¢ untranslated region (3¢ UTR) preceding a poly(A) tail
C) Chemical factors, such as hormones
D) Small interfering RNAs (siRNAs)
E) All of these are correct.

Accepted Answer

All of the listed factors can affect RNA transcript stability in the cytoplasm. The addition of a 3' Poly A tail can increase the stability, while the sequence and length of the 3' UTR, as well as chemical factors like hormones, can affect degradation rates. Small interfering RNAs can also contribute to RNA degradation.