A Disadvantage of L Cloning Vectors Is

Question

A disadvantage of l cloning vectors is:
A) An inability to accommodate eukaryotic DNA
B) The absence of unique restriction sites
C) An inability to be packaged in vitro
D) A strict limit on the insert size (no larger than 10kb)
E) The instability of large foreign DNA inserts

Accepted Answer

Lambda (λ) cloning vectors can accommodate larger DNA inserts compared to plasmids, but they can become unstable with very large inserts, leading to potential loss or rearrangement of the inserted DNA.