Which of the Following Statements About the Mismatch Repair Pathway

Question

Which of the following statements about the mismatch repair pathway is not correct?
A) MutH contains a GATC-specific endonuclease activity
B) Cleavage of the unmethylated strand only occurs 3' to the mismatch
C) This system of repair utilizes MutH, MutL, MutS, and UvrD
D) The repair system can distinguish the template strand from the newly synthesized strand
E) All of these are correct

Accepted Answer

The cleavage of the unmethylated strand occurs 5' to the mismatch, not 3' to the mismatch. The correct statement would be that cleavage of the unmethylated strand only occurs 5' to the mismatch. Therefore, option B is incorrect. The other options are correct statements about the mismatch repair pathway.